期刊
CIRCULATION RESEARCH
卷 120, 期 1, 页码 166-178出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1161/CIRCRESAHA.116.309362
关键词
adult stem cells; germ layers; hematopoietic stem cells; parental imprinting; ras-GRF1; stem cells; very small embryonic like stem cells
资金
- National Institutes of Health [R01 DK074720, R01HL112788]
- Stella and Henry Endowment
- Harmonia NCN [UMO-2014/14/M/NZ3/00475]
- Basic Science Research Program through the National Research Foundation of Korea [2015R1A2A1A15054754]
- National Research Foundation of Korea [2015R1A2A1A15054754] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
Evidence has accumulated that adult hematopoietic tissues and other organs contain a population of dormant stem cells (SCs) that are more primitive than other, already restricted, monopotent tissue-committed SCs (TCSCs). These observations raise several questions, such as the developmental origin of these cells, their true pluripotent or multipotent nature, which surface markers they express, how they can be efficiently isolated from adult tissues, and what role they play in the adult organism. The phenotype of these cells and expression of some genes characteristic of embryonic SCs, epiblast SCs, and primordial germ cells suggests their early-embryonic deposition in developing tissues as precursors of adult SCs. In this review, we will critically discuss all these questions and the concept that small dormant SCs related to migratory primordial germ cells, described as very small embryonic-like SCs, are deposited during embryogenesis in bone marrow and other organs as a backup population for adult tissue-committed SCs and are involved in several processes related to tissue or organ rejuvenation, aging, and cancerogenesis. The most recent results on successful ex vivo expansion of human very small embryonic-like SC in chemically defined media free from feeder-layer cells open up new and exciting possibilities for their application in regenerative medicine.
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