期刊
CANCER CELL
卷 31, 期 1, 页码 5-19出版社
CELL PRESS
DOI: 10.1016/j.ccell.2016.12.006
关键词
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资金
- American Association for Cancer Research
- Pancreatic Cancer Action Network [13-70-25-LYSS]
- National Pancreas Foundation
- Sidney Kimmel Foundation
- Damon Runyon Cancer Research Foundation [DFS-09-14]
- American Gastroenterological Association
Pancreatic ductal adenocarcinoma is on pace to become the second leading cause of cancer-related death. The high mortality rate results from a lack of methods for early detection and the inability to successfully treat patients once diagnosed. Pancreatic cancer cells have extensively reprogrammed metabolism, which is driven by oncogene-mediated cell-autonomous pathways, the unique physiology of the tumor microenvironment, and interactions with non-cancer cells. In this review, we discuss how recent efforts delineating rewired metabolic networks in pancreatic cancer have revealed new in-roads to develop detection and treatment strategies for this dreadful disease.
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