期刊
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
卷 67, 期 -, 页码 66-76出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.dci.2016.11.001
关键词
SOCS; JAK/STAT signaling; IPNV; SAV; Interferons; Atlantic salmon
资金
- Aquaculture program of The Research Council of Norway [185217/40]
- UiT The Artic University of Norway
- Tromso Research Foundation [2012/464]
The SOCS proteins are regulators of JAK/STAT signaling. A number of viral infections has been associated with SOCS upregulation. Here we report that SOCS1 mRNA expression is up-regulated in salmon alphavirus (SAV3) infected TO cells, while infectious pancreatic necrosis virus infection has a negligible effect. SAV3 infected salmon showed increased SOCS1 mRNA levels in heart correlating with increased viral transcripts. Together, the in vitro and in vivo data suggests that SAV3-induced SOCS1 expression may affect the outcome of the virus infection. Using CHSE-214 cells overexpressing SOCS1 we revealed increased SAV3 replication compared to control, suggesting that SOCS1 suppress the antiviral capacity of the cells. In IFNa1-treated cells, the suppression of viral replication was partially rescued by SOCS1 overexpression. The increased viral replication in SOCS1 transgene cells was likely a result of impaired IFN-signaling and the reduced expression of interferon-stimulated genes in the transgene cells underscores this. (C) 2016 Elsevier Ltd. All rights reserved.
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