期刊
DYES AND PIGMENTS
卷 137, 期 -, 页码 91-100出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.dyepig.2016.10.001
关键词
Prodrugs; Coumarins; Oxazoles; Butyric acid; Photocleavable protecting groups; Photolysis
资金
- Fundacao para a Ciencia e Tecnologia (FCT, Portugal)
- FEDER (European Fund for Regional Development)-COMPETE-QREN-EU [PEst-C/QUI/UI0686/2013 (FCOMP-01-0124-FEDER-022716), SFRH/BD/80813/2011]
- FCT
- Fundação para a Ciência e a Tecnologia [SFRH/BD/80813/2011] Funding Source: FCT
New coumarin fused oxazoles were investigated as photosensitive units for carboxylic acid groups using butyric acid as a model compound. 6-Oxo-6H-benzopyrano[6,7-d]oxazol-8-yl)methyl derivatives possessing various (hetero)aromatic substituents at position 2 of the heterocyclic system were used in the synthesis of ester conjugates of butyric acid. Photolysis at selected wavelengths in methanol/HEPES buffer (80:20) solutions, monitored by HPLC/UV and 1H NMR, resulted in the complete release of butyric acid. The shorter irradiation times for cleavage at longer wavelengths occurred for the conjugate with a 4-oxo-4H-benzopyran-2-ylsubstituent and thus (6-oxo-2-(4-oxo-4H-benzopyran-2-y1)-6H-benzopyrano [6,7-d]oxazol-8-yl)methyl has potential as a candidate photosensitive moiety for butyric acid prodrugs. (C) 2016 Elsevier Ltd. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据