期刊
ADDICTIVE BEHAVIORS
卷 65, 期 -, 页码 296-301出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.addbeh.2016.08.021
关键词
Longitudinal; Medical use; Nonmedical use; Sedative; Anxiolytic; Substance use disorders
资金
- National Institute on Drug Abuse, National Institutes of Health [R01DA001411, R01DA016575, R01DA031160, R01DA036541]
Objectives: This study assessed the longitudinal associations between medical and nonmedical use of prescription sedatives/anxiolytics (NMPSA) during adolescence (age 18) and substance use disorder (SUD) symptoms during adulthood (age 35). Methods: Multiple cohorts of nationally representative samples of U.S. high school seniors (n = 8373) were surveyed via self-administered questionnaires and followed longitudinally from adolescence (age 18, 1976-1996) to adulthood (age 35, 1993-2013). Results: An estimated 20.1% of adolescents reported lifetime medical or nonmedical use of prescription sedatives/ anxiolytics. Among adolescents who reported medical use of prescription sedatives/anxiolytics, 44.9% also reported NMPSA by age 18. Based on multivariate analyses that included age 18 sociodemographic and other substance use controls, medical use of prescription sedatives/anxiolytics without any history of NMPSA during adolescence was not associated with SUD symptoms in adulthood relative to adolescents with no prescription sedative/anxiolytic use. In contrast, adolescents with-a history of both medical and nonmedical use of prescription sedatives/anxiolytics and adolescents who reported only NMPSA had between two to three times greater odds of SUD symptoms in adulthood relative to adolescents with no prescription sedative/anxiolytic use and those who reported only medical use of prescription sedatives/anxiolytics. Conclusions: One in every five U.S. high school seniors reported ever using prescription sedatives/anxiolytics either medically or nonmedically. This study provides compelling evidence that the medical use of prescription sedatives/anxiolytics (without any NMPSA) during adolescence is not associated with increased risk of SUD symptoms in adulthood while any NMPSA during adolescence serves as a signal for SUDs in adulthood. (C) 2016 Elsevier Ltd. All rights reserved.
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