期刊
BIOLOGICAL PSYCHIATRY
卷 81, 期 2, 页码 136-144出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.biopsych.2016.07.008
关键词
Aging; Epigenetic; Immunosenescence; Insomnia; Methylation; Sleep
资金
- University of California, Los Angeles, Cousins Center for Psychoneuroimmunology
- National Institutes of Health (NIH)/National Institute on Aging Grant [K01 AG044462, 5R01AG042511-02, R01 AG034588, R01 AG026364]
- NIH/National Cancer Institute [R01 CA160245]
- NIH/National Institute on Drug Abuse [R01 DA032922]
- NIH/National Heart, Lung, and Blood Institute (NHLBI) [60442456 BAA23, R01 HL095799-01, P30 AG017265, R24AG037898]
- NHLBI
- U.S. Department of Health and Human Services [HHSN268201100046C, HHSN268201600003C, HHSN268201600002C, HHSN268201600004C, HHSN268201600001C, HHSN271201100004C]
- NIH
BACKGROUND: Insomnia symptoms are associated with vulnerability to age-related morbidity and mortality. Cross-sectional data suggest that accelerated biological aging may be a mechanism through which sleep influences risk. A novel method for determining age acceleration using epigenetic methylation to DNA has demonstrated predictive utility as an epigenetic clock and prognostic of age-related morbidity and mortality. METHODS: We examined the association of epigenetic age and immune cell aging with sleep in the Women's Health Initiative study (N = 2078; mean 64.5 +/- 7.1 years of age) with assessment of insomnia symptoms (restlessness, difficulty falling asleep, waking at night, trouble getting back to sleep, and early awakenings), sleep duration (short sleep 5 hours or less; long sleep greater than 8 hours), epigenetic age, naive T cell (CD81CD45RA1CCR71), and late differentiated T cells (CD81CD28-CD45RA-). RESULTS: Insomnia symptoms were related to advanced epigenetic age (beta +/- SE = 1.02 +/- 0.37, p = .005) after adjustments for covariates. Insomnia symptoms were also associated with more late differentiated T cells (b 6 SE 5 0.59 +/- 0.21, p = .006), but not with naive T cells. Self-reported short and long sleep duration were unrelated to epigenetic age. Short sleep, but not long sleep, was associated with fewer naive T cells (p < .005) and neither was related to late differentiated T cells. CONCLUSIONS: Symptoms of insomnia were associated with increased epigenetic age of blood tissue and were associated with higher counts of late differentiated CD8+ T cells. Short sleep was unrelated to epigenetic age and late differentiated cell counts, but was related to a decline in naive T cells. In this large population-based study of women in the United States, insomnia symptoms are implicated in accelerated aging.
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