期刊
CANCER LETTERS
卷 385, 期 -, 页码 12-20出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2016.10.042
关键词
Irradiation; Caspase 3; Angiogenesis; COX-2/PGE(2); VEGF-A
类别
资金
- National Natural Science Foundation of China [81120108017, 81572951, 81172030, 81502648, 81572788]
- National Institutes of Health, USA [ES024015, CA155270]
Vascular recovery or re-angiogenesis after radiotherapy plays a significant role in tumor recurrence, whereas molecular mechanisms of this process remain elusive. In this work, we found that dying glioma cells promoted post-irradiation angiogenesis through a caspase 3 dependent mechanism. Evidence in vitro and in vivo indicated that caspase 3 inhibition undermined proangiogenic effects of dying glioma cells. Proteolytic inactivation of caspase 3 in glioma cells reduced tumorigenicity. Importantly, we identified that NF-kappa B/COX-2/PGE(2) axis acted as downstream signaling of caspase 3, mediating proangiogenic response after irradiation. Additionally, VEGF-A, regulated by caspase 3 possibly through phosphorylated elF4E, was recognized as another downstream factor participating in the proangiogenic response. In conclusion, these data demonstrated that caspase 3 in dying glioma cells supported the proangiogenic response after irradiation by governing NF-kappa B/COX-2/PGE(2) axis and p-eIF4E/VEGF-A signaling. While inducing caspase 3 activation has been a generally-adopted notion in cancer therapeutics, our study counterintuitively illustrated that caspase 3 activation in dying glioma cells unfavorably supported post-irradiation angiogenesis. This double-edged role of caspase 3 suggested that taming caspase 3 from the opposite side, not always activating it, may provide novel therapeutic strategies due to restricted post-irradiation angiogenesis. (C) 2016 Elsevier Ireland Ltd. All rights reserved.
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