The study of drying and pattern formation of whole human blood drops and the effect of thalassaemia and neonatal jaundice on the patterns

In this paper, we report a study on the drying process of whole human blood drops on glass substrates. It was shown previously (Brutin et al., 2011) that some diseases can change the patterns in dried drops of blood, but the reason behind the differences has not been discussed. In this paper, we explain the physical reasons behind the differences in patterns analytically in a quantitative and detailed way. We have analysed samples of three groups: healthy adults, adults having thalassaemia, and infants with jaundice. We investigate the formation of large cracks in three groups and measure the length of cracks for the jaundice group and find a relation between the bilirubin level and the length of large cracks. Then we show that the height profile of the dried drops is different for the three groups. We also compare the dynamics of evaporation and pattern formation for the three groups. Finally we explain the differences based on different physical properties like volume fraction, height, and viscosity. We show that valuable information about blood composition as well as the paroxysm of the mentioned diseases can be extracted just by analysing the patterns formed in dried drops. (C) 2016 Elsevier B.V. All rights reserved.