期刊
BRAIN BEHAVIOR AND IMMUNITY
卷 59, 期 -, 页码 333-345出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.bbi.2016.08.018
关键词
Microglia; White matter injury; Neurodevelopment; Inflammation; Prematurity; Therapeutics
资金
- CIHR, Institute of Human Development, Child and Youth Health (IHDCYH) [126790, 136908]
- Fonds de recherche en sante du Quebec (FRSQ)
- University of Montreal
- Centre de recherche de l'Hopital Ste-Justine
- Swedish Research Council [VR 2012-2992]
- Leducq Foundation [DSRR_P34404]
- Swedish Brain Foundation [FO2015-0190]
- Ahlen-stiftelsen
- Soderberg Foundation
Microglia, mainly known for their role in innate immunity and modulation of neuroinflammation, play an active role in central nervous system development and homeostasis. Depending on the context and environmental stimuli, microglia adopt a broad spectrum of activation status from pro-inflammatory, associated with neurotoxicity, to anti-inflammatory linked to neuroprotection. Pro-inflammatory microglial activation is a key hallmark of white matter injury in preterm infants and is involved in developmental origin of adult neurological diseases. Characterization of neonatal microglia function in brain development and inflammation has allowed the investigation of promising therapeutic targets with potential long-lasting neuroprotective effects. True prevention of neuro-degenerative diseases might eventually occur as early as the perinatal period. (C) 2016 Elsevier Inc. All rights reserved.
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