期刊
BIOSENSORS & BIOELECTRONICS
卷 89, 期 -, 页码 411-416出版社
ELSEVIER ADVANCED TECHNOLOGY
DOI: 10.1016/j.bios.2016.05.064
关键词
Graphitic carbon nitride nanodots; Reductant; Silver nanoparticles; Biothiols; Detection
类别
资金
- National Natural Science Foundation of China [21275051, 21475043]
- Doctoral Fund of Ministry of Education of China [20134306110006]
- Science and Technology Department of Hunan Province [2014FJ6034]
- Hunan Provincial Innovation Foundation for Postgraduate [CX2014B223]
The graphitic carbon nitride nanodots (g-C3N4-dots) were synthesized by a simple electrochemical tailoring process from bulk graphitic carbon nitride (g-C3N4) under alkaline solution for the first time. Compared with the bulk g-C3N4, the novel g-C3N4-dots not only exhibit enhanced fluorescence and excellent dispersion stability in water but also show the reducibility for the reduction of Ag+ to AgNPs at 60 degrees C. The biothiols can bound with Ag+ through formation of biothiol-Ag+ complex to consume the Ag+ and act as capping agent to prevent the growth of AgNPs, which cause the decrease of the absorption peak of the AgNPs. Therefore, an optical sensor was developed for the detection of biothiols based on the change of the plasmon resonance absorption peak of the AgNPs. The proposed method exhibits excellent sensitivity and selectivity to biothiols with low detection limit for cysteine (Cys), homocysteine (Hcy), and glutathione (GSH) with 11.5, 16.1, and 15.5 nM, respectively. This method also has been successfully applied for the detection of biothiols in human serum with satisfactory results. (C) 2016 Elsevier B.V. All rights reserved.
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