期刊
BIOLOGICAL & PHARMACEUTICAL BULLETIN
卷 40, 期 1, 页码 61-67出版社
PHARMACEUTICAL SOC JAPAN
DOI: 10.1248/bpb.b16-00598
关键词
Streptococcus pneumoniae; pneumolysin; amentoflavone; oligomerization
资金
- National Nature Science Foundation of China [31130053]
- China Postdoctoral Science Foundation [2016M591486]
Pneumolysin (PLY) is a devastating bacterial protein toxin of Streptococcus pneumoniae that punctures the cytomembrane, leading to pathological reactions, such as cell disruption and inflammation. Drugs capable of closely impacting the toxin are considered advantageous in the treatment of bacterial infections. Amentoflavone (AMF) is a chemical substance extracted from traditional Chinese herbs. Previous studies have demonstrated that AMF has multiple pharmacological effects and mentioned without attenuating pneumolysin-mediated cytotoxicity. This work focuses on the influence of AMF on inhibitory hemolytic mechanisms. AMF interacts with the toxin at Ser254, Glu277, Arg359, and effectively weakens the oligomerization of wild-type PLY and provides considerable protection against pneumolysin-mediated human alveolar epithelial (A549) cell damage. The results of our study demonstrate that AMF could be a candidate against pneumolysin-related injury.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据