期刊
CELL
卷 168, 期 3, 页码 344-361出版社
CELL PRESS
DOI: 10.1016/j.cell.2016.12.034
关键词
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资金
- Deutsche Forschungsgemeinschaft [SFB1118, SFB1036, GA2075/3-1]
- Dietmar Hopp Stiftung
- National Institute of Diabetes and Digestive and Kidney Diseases
- National Heart, Lung, and Blood Institute of the National Institutes of Health [R01 DK095112, R01 DK090554, R01 HL102449]
- Merganser Biotech
- Ionis Pharmaceuticals
200 billion red blood cells (RBCs) are produced every day, requiring more than 2 x 10(15) iron atoms every second to maintain adequate erythropoiesis. These numbers translate into 20 mL of blood being produced each day, containing 6 g of hemoglobin and 20 mg of iron. These impressive numbers illustrate why the making and breaking of RBCs is at the heart of iron physiology, providing an ideal context to discuss recent progress in understanding the systemic and cellular mechanisms that underlie the regulation of iron homeostasis and its disorders.
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