期刊
NATURE REVIEWS IMMUNOLOGY
卷 17, 期 2, 页码 130-143出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nri.2016.129
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资金
- US National Institutes of Health Grant [AI103618]
- University of Missouri Research Board Award
- Intramural Research Program of the National Institute of Environmental Health Sciences, US National Institutes of Health
Nearly 60 CCCH zinc finger proteins have been identified in humans and mice. These proteins are involved in the regulation of multiple steps of RNA metabolism, including mRNA splicing, polyadenylation, transportation, translation and decay. Several CCCH zinc finger proteins, such as tristetraprolin (TTP), roquin 1 and MCPIP1 (also known as regnase 1), are crucial for many aspects of immune regulation by targeting mRNAs for degradation and modulation of signalling pathways. In this Review, we focus on the emerging roles of CCCH zinc finger proteins in the regulation of immune responses through their effects on cytokine production, immune cell activation and immune homeostasis.
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