期刊
CHEMOSPHERE
卷 168, 期 -, 页码 1042-1050出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.chemosphere.2016.10.105
关键词
Acidic drugs; Method validation; Derivatization; GC-MS; Surface water; Umgeni river
资金
- Water Research Commission of South Africa
- NRF South Africa
A method was optimized for derivatization, separation, detection and quantification of salicylic acid, acetylsalicylic acid, nalidixic acid, ibuprofen, phenacetin, naproxen, ketoprofen, meclofenamic acid and diclofenac in surface water using gas chromatography-mass spectrometry. For most of the acidic drugs, recovery was in the range 60-110% and the percent standard deviation was below 15% for the entire method, with limits of detection ranging from 0.041 to 1.614 mu g L-1. The developed method was applied in the analysis of acidic drugs in Umgeni River system, KwaZulu-Natal South Africa. All of the selected acidic drugs were detected and quantified, their concentration in Umgeni River system ranged from 0.0200 to 68.14 mu g L-1. (C) 2016 Elsevier Ltd. All rights reserved.
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