期刊
BIOORGANIC & MEDICINAL CHEMISTRY
卷 25, 期 3, 页码 1122-1131出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmc.2016.12.028
关键词
Bis(indolyl)methanes; Nitrosoalkenes; Azoalkenes; Indoles; Hetero-Diels-Alder reaction; Anti-cancer activity; Leukaemia; Lymphoma
资金
- Portuguese Agency for Scientific Research
- Fundacao para a Ciencia e a Tecnologia (FCT) [007630 UID/QUI/00313/2013]
- COMPETE-UE
- FCT
- Coimbra Chemistry Centre [CQC-QO-BPD-2015]
- Fundação para a Ciência e a Tecnologia [UID/QUI/00313/2013] Funding Source: FCT
A novel synthetic approach to bis(indolyl)methanes has been established. Our one-pot synthetic strategy based on two consecutive hetero-Diels-Alder cycloaddition reactions of electrophilic conjugated nitrosoalkenes with indoles was extended to a range of new 1-hydroxyiminomethyl-bis(indolyl) methanes. Furthermore, a similar and broad range approach was applied to the synthesis of previously unknown 1-hydrazonomethyl-bis(indolyl)methanes. The biological evaluation of the new bis(indolyl) methanes as anti-cancer agents was investigated. (C) 2016 Elsevier Ltd. All rights reserved.
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