Bedtime Blood Pressure Chronotherapy Significantly Improves Hypertension Management

Consistent evidence of numerous studies substantiates the asleep blood pressure (BP) mean derived from ambulatory BP monitoring (ABPM) is both an independent and a stronger predictor of cardiovascular disease risk than are daytime clinic BP measurements or the ABPM-determined awake or 24-hour BP means. Cost-effective adequate control of sleep-time BP is of marked clinical relevance. Ingestion time, according to circadian rhythms, of hypertension medications of 6 different classes and their combinations, significantly improves BP control, particularly sleep-time BP, and reduces adverse effects. Recent findings authenticate therapeutic reduction of the sleep-time BP by a bedtime hypertension treatment strategy entailing the entire daily dose of >= 1 hypertension medications significantly reduces not only CVD risk but also progression toward new-onset type 2 diabetes and renal disease.