期刊
ACTA BIOMATERIALIA
卷 49, 期 -, 页码 507-520出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.actbio.2016.11.071
关键词
Biodistribution; Cobalt ferrite; Multimodal imaging; Nanoprobes; Monocyte-macrophages; Magnetic resonance imaging
资金
- Nebraska Research Initiative (NRI)
- University of Nebraska Foundation
- NIH [DA028555, NS036126, NS034239, MH064570, NS043985, MH062261, AG043540]
- DOD [421-20-09A]
- Carol Swarts Emerging Neuroscience Fund (HEG)
- Nebraska Research Initiative
- Department of Pharmacology and Experimental Neuroscience
The size, shape and chemical composition of europium (Eu3+) cobalt ferrite (CFEu) nanoparticles were optimized for use as a multimodal imaging nanoprobe for combined fluorescence and magnetic resonance bioimaging. Doping Eu3+ ions into a CF structure imparts unique bioimaging and magnetic properties to the nanostructure that can be used for real-time screening of targeted nanoformulations for tissue biodistribution assessment. The CFEu nanoparticles (size similar to 7.2 nm) were prepared by solvothermal techniques and encapsulated into poloxamer 407-coated mesoporous silica (Si-P407) to form superparamagnetic monodisperse Si-CFEu nanoparticles with a size of similar to 140 nm. Folic acid (FA) nanoparticle decoration (FA-Si-CFEu, size similar to 140 nm) facilitated monocyte-derived macrophage (MDM) targeting. FA-Si-CFEu MDM uptake and retention was higher than seen with Si-CFEu nanoparticles. The transverse relaxivity of both Si-CFEu and FA-Si-CFEu particles were r(2) = 433.42 mM(-1) s(-1) and r(2) = 419.52 mM(-1) s(-1) (in saline) and r(2) = 736.57 mM(-1) s(-1) and r(2) = 814.41 mM(-1) s-1 (in MDM), respectively. The results were greater than a log order-of-magnitude than what was observed at replicate iron concentrations for ultra small superparamagnetic iron oxide (USPIO) particles (r(2) = 31.15 mM(-1) s(-1) in saline) and paralleled data sets obtained for T-2 magnetic resonance imaging. We now provide a developmental opportunity to employ these novel particles for theranostic drug distribution and efficacy evaluations. Statement of Significance A novel europium (Eu3+) doped cobalt ferrite (Si-CFEu) nanoparticle was produced for use as a bioimaging probe. Its notable multifunctional, fluorescence and imaging properties, allows rapid screening of future drug biodistribution. Decoration of the Si-CFEu particles with folic acid increased its sensitivity and specificity for magnetic resonance imaging over a more conventional ultrasmall superparamagnetic iron oxide particles. The future use of these particles in theranostic tests will serve as a platform for designing improved drug delivery strategies to combat inflammatory and infectious diseases. (C) 2016 Acta Materialia Inc. Published by Elsevier Ltd.
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