期刊
CELLULAR SIGNALLING
卷 31, 期 -, 页码 26-30出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.cellsig.2016.12.007
关键词
APN; CD13; MMP; stratum; Exosome; Biomarker; 14-3-3
类别
资金
- Fonds de Recherche du Quebec - Sante
- Canadian Institutes of Health Research
- Multiple Sclerosis Society of Canada
14-3-3s are a family of adaptor proteins with a wide range of roles in cell signaling. Although they are primarily localized within the cytosol, 14-3-3s are also known to be present in the extracellular environment. Externalization of 14-3-3 can occur as a result of cell death or physiologically via release in exosomes. Interesting biological activities with relevance for tissue homeostasis and disease are now being described for extracellular 14-3-3s. Moreover, aminopeptidase N (APN) has been identified as a cell surface receptor for 14-3-3s. Here we review the array of bioactivities that have been ascribed to extracellular 14-3-3s and discuss applications as biomarkers and as targets for drug development. (C) 2016 Elsevier Inc. All rights reserved.
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