期刊
HAEMATOLOGICA
卷 102, 期 12, 页码 2125-2133出版社
FERRATA STORTI FOUNDATION
DOI: 10.3324/haematol.2017.171157
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- Gruppo Italiano Trapianto di Midollo Osseo (GITMO), FARITMO, Genova
- AIRC, Milano
Patients with acute graft-versus-host disease (GvHD) grade I were randomized to an observation arm (n=85) or to a treatment arm (n=86) consisting of 6-methylprednisolone 1 mg/kg/day, after stratification for age and donor type. The primary end point was development of grade II-IV GvHD. The cumulative incidence of grade II-IV GvHD was 50% in the observation arm and 33% in the treatment arm (P=0.005). However, grade III-IV GvHD was comparable (13% vs. 10%, respectively; P=0.6), and this was true for sibling and alternative donor transplants. Moderate/severe chronic GvHD was also comparable (17% vs. 9%). In multivariate analysis, an early interval between transplant and randomization (
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