期刊
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
卷 101, 期 3, 页码 1227-1237出版社
SPRINGER
DOI: 10.1007/s00253-016-8073-8
关键词
Draft genome sequence; Probiotics; Bacteriocin; Weissella cibaria
资金
- Academic Technology Development Program of the Ministry of Economic Affairs, Republic of China [101-EC-17-A-17-S1-197, 102-EC-17-A-17-S1-197, 103-EC-17-A-17-S1-197]
- Bioinformatics Consortium of Taiwan (MOST) [103-2319-B-010-002]
Weissella cibaria 110 was isolated from plaa-som, a Thai fermented fish product, and known to produce the weissellicin 110 bacteriocin. We carried out comprehensive comparative genomic analysis of W. cibaria 110 with four other non-bacteriocin-producing W. cibaria strains and identified potential antibiotic-resistant genes. We further identified a type III restriction-modification system, a TA system, and a bacteriocin gene cluster that are unique in W. cibaria 110. Genes related to bacteriocin biosynthesis are organized in clusters and are encoded with minimum genetic machinery consisting of structural cognate immunity genes, including ABC transporter and immunity protein. Finally, we predicted W. cibaria 110 to produce a class IId bacteriocin, weissellicin 110, which is 31 amino acids in length and contains a 21-amino-acid N-terminal leader peptide. This is the first bacteriocin-producing sequencing genome in W. cibaria, and we describe the difference between the bacteriocin-producing and non bacteriocin-producing strains from genome point of view.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据