期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 56, 期 6, 页码 1486-+出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201609277
关键词
antibiotics; bacteria; drug discovery; MRSA; peptides
资金
- Special Fund for Agro-scientific Research in the Public Interest [201203069-2]
- Fund of Modern Agriculture Industry System Innovation in Beijing City Team [1051-25015022]
The emergence and rapid spread of methicillin-resistant Staphylococcus aureus (MRSA) poses a serious threat to public health. New antibiotics and strategies are urgently needed to combat S. aureus associated infections. Bacaucin, a novel cyclic lipopeptide from Bacillus subtilis CAU21, is reported. Bacaucin shows broad antibacterial activity against Gram-positive bacteria, but is also hemolytic and cytotoxic. However, bacaucin-1, a bacaucin-inspired ring-opened heptapeptide, shows specific antibacterial activity against MRSA by a membrane-disruptive mechanism without detectable toxicity to mammalian cells or induction of bacterial resistance. Bacaucin-1 was efficient in preventing infections in both in vitro and in vivo models and is a valuable prototype antibiotic with high potential against S. aureus infections.
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