期刊
CHEMISTRY-A EUROPEAN JOURNAL
卷 23, 期 8, 页码 1853-1859出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.201604411
关键词
Aflatoxin M1; electrochemiluminescence; resonance energy transfer; ruthenium; target-induced circular exponential amplification
资金
- NNSF of China [51473136, 21575116, 21675129, 21675130]
- Fundamental Research Funds for the Central Universities, China [XDJK2015A002]
The intermolecular electrochemiluminescence resonance energy transfer (ECL-RET) between luminol and Ru(bpy) 3(2+) was studied extensively to achieve the sensitive bioanalysis owing to the perfect spectral overlap of the donor and acceptor, but it still suffers from the challenging issue of low energy- transfer efficiency. The intramolecular ECL-RET towards the novel ECL compound containing the donor of luminol and the acceptor of Ru(bpy)(2)(mcpbpy)(2+)(Lum-Ru) was designed and investigated. With the high-efficient ECL-RET in one molecule, the highly intense ECL signal of Lum- Ru was obtained owing to the short path of energy transmission and less energy loss between luminol and Ru(bpy)(2)(mcpbpy)(2+). Lum-Ru was further applied to construct a signal- off electrochemiluminescence (ECL) aptasensor for ultrasensitive detection of a harsh carcinogen of Aflatoxin M1 (AFM1). This sensing platform also provides a significant boost for the trace detection of other biomolecules in clinical analysis.
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