期刊
CURRENT OPINION IN BIOTECHNOLOGY
卷 43, 期 -, 页码 34-40出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.copbio.2016.08.001
关键词
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资金
- Morgridge Institute for Research, Madison WI
- NIH [R01GM109046, P41GM103399, R01 GM 066041, U24 (SECIM) DK097209-01A1]
- Georgia Research Alliance [NIH P41GM111135, NIH P20 RR-17675, P30GM103335, R01 CA163649-01A1, R01 AI087668-01A1, NIH R01GM085291, P30CA015704]
- Genome Canada support
- Alberta Innovates [201201143] Funding Source: researchfish
The two leading analytical approaches to metabolomics are mass spectrometry (MS) and nuclear magnetic resonance (NMR) spectroscopy. Although currently overshadowed by MS in terms of numbers of compounds resolved, NMR spectroscopy offers advantages both on its own and coupled with MS. NMR data are highly reproducible and quantitative over a wide dynamic range and are unmatched for determining structures of unknowns. NMR is adept at tracing metabolic pathways and fluxes using isotope labels. Moreover, NMR is non-destructive and can be utilized in vivo. NMR results have a proven track record of translating in vitro findings to in vivo clinical applications.
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