期刊
RESPIRATORY RESEARCH
卷 18, 期 -, 页码 -出版社
BMC
DOI: 10.1186/s12931-017-0511-3
关键词
Idiopathic pulmonary fibrosis; Acute exacerbation; Bacterial infection; 16S
资金
- Asmarley Trust
- Wellcome Trust
- NIHR Clinician Scientist Fellowship (NIHR) [CS-2013-13-017]
- NIHR Respiratory Disease Biomedical Research Unit at the Royal Brompton
- Harefield NHS Foundation Trust
- AHSC Biomedical Research Centre at Imperial College London
- National Institutes of Health [HL097163, HL092870]
- Asthma UK [MRC-AsthmaUKCentre, MRC-Asthma UK Centre] Funding Source: researchfish
- British Lung Foundation [BLF-RMF15-16] Funding Source: researchfish
- Medical Research Council [G1000758] Funding Source: researchfish
- National Institute for Health Research [NF-SI-0512-10126, CS-2013-13-017] Funding Source: researchfish
- National Institutes of Health Research (NIHR) [CS-2013-13-017] Funding Source: National Institutes of Health Research (NIHR)
Acute exacerbations of idiopathic pulmonary fibrosis (AE-IPF) have been defined as events of clinically significant respiratory deterioration with an unidentifiable cause. They carry a significant mortality and morbidity and while their exact pathogenesis remains unclear, the possibility remains that hidden infection may play a role. The aim of this pilot study was to determine whether changes in the respiratory microbiota occur during an AE-IPF. Bacterial DNA was extracted from bronchoalveolar lavage from patients with stable IPF and those experiencing an AE-IPF. A hyper-variable region of the 16S ribosomal RNA gene (16S rRNA) was amplified, quantified and pyrosequenced. Culture independent techniques demonstrate AE-IPF is associated with an increased BAL bacterial burden compared to stable disease and highlight shifts in the composition of the respiratory microbiota during an AE-IPF.
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