期刊
BONE
卷 95, 期 -, 页码 1-4出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.bone.2016.10.027
关键词
Metabolomics; Metabolite; Gly-Gly; Cystine; Postmenopausal women; Low bone mineral density
资金
- Ministry of Education, Culture, Sports, Science and Technology of Japan
- Japan Agency for Medical Research and Development
- Eli Lilly Scientific foundation
- Grants-in-Aid for Scientific Research [15H04963, 15K10490, 16K10917] Funding Source: KAKEN
Osteoporosis is characterized as a metabolic disorder of bone tissue, and various metabolic markers are now available to support its diagnosis and evaluate treatment effects. Substances produced as end products of metabolomic activities are the correlated factors to the biological or metabolic status, and thus, metabolites are considered highly sensitive markers of particular pathological states, including osteoporosis. Here we undertook comprehensive serum metabolomics analysis in postmenopausal women with or without low bone mineral density (low BMD vs controls) for the first time using capillary electrophoresis/mass spectrometry. Among the metabolites tested, 57 were detected in sera. Levels of hydroxyproline, Gly-Gly and cystine, differed significantly between groups, with Gly-Gly and cystine significantly lower in the low BMD group and hydroxyproline, a reported marker of osteoporosis, significantly higher. Levels of TRACP5b, a bone resorption marker, were significantly higher in the low BMD group, supporting the study's validity. Taken together, our findings represent novel metabolomic profiling in low BMD in postmenopausal women. (C) 2016 Elsevier Inc All rights reserved.
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