期刊
GENETICS
卷 208, 期 2, 页码 525-536出版社
GENETICS SOCIETY AMERICA
DOI: 10.1534/genetics.117.300546
关键词
Multiparent Advanced Generation Inter-Cross (MAGIC); multiparental populations; three-way epistatic interactions; sure dependence screening; multilocus association model; multiparental populations; MPP
资金
- German Federal Ministry of Education and Research
- Europaische Fonds fur Regionale Entwicklung (Forderkennzeichen) [z1011bc001]
Flowering time is a well-known complex trait in crops and is influenced by many interacting genes. In this study, Mathew et al. identify two-way and.... Gene-by-gene interactions, also known as epistasis, regulate many complex traits in different species. With the availability of low-cost genotyping it is now possible to study epistasis on a genome-wide scale. However, identifying genome-wide epistasis is a high-dimensional multiple regression problem and needs the application of dimensionality reduction techniques. Flowering Time (FT) in crops is a complex trait that is known to be influenced by many interacting genes and pathways in various crops. In this study, we successfully apply Sure Independence Screening (SIS) for dimensionality reduction to identify two-way and three-way epistasis for the FT trait in a Multiparent Advanced Generation Inter-Cross (MAGIC) barley population using the Bayesian multilocus model. The MAGIC barley population was generated from intercrossing among eight parental lines and thus, offered greater genetic diversity to detect higher-order epistatic interactions. Our results suggest that SIS is an efficient dimensionality reduction approach to detect high-order interactions in a Bayesian multilocus model. We also observe that many of our findings (genomic regions with main or higher-order epistatic effects) overlap with known candidate genes that have been already reported in barley and closely related species for the FT trait.
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