期刊
CURRENT OPINION IN BIOTECHNOLOGY
卷 43, 期 -, 页码 8-16出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.copbio.2016.07.003
关键词
-
资金
- Strategic International Collaborative Research Program (SICORP), JST
The advent of the genome-editing era greatly increases the opportunities for synthetic biology research that aims to enhance production of potentially useful bioactive metabolites in heterologous hosts. A wide variety of sulfur (S)-containing metabolites (S-metabolites) are known to possess bioactivities and health-promoting properties, but finding them and their chemical assignment using mass spectrometry-based metabolomics has been difficult. In this review, we highlight recent advances on the targeted metabolomic analysis of S metabolites (S-omics) in plants using ultrahigh resolution mass spectrometry. The use of exact mass and signal intensity differences between S-32-containing monoisotopic ions and counterpart S-34 isotopic ions exploits an entirely new method to characterize S-metabolites. Finally, we discuss the availability of S-omics for synthetic biology.
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