期刊
BIOMATERIALS
卷 117, 期 -, 页码 105-115出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.biomaterials.2016.11.046
关键词
Soft tissue; Bioink; 3D printing; Silk; Regeneration
资金
- NIH [P41 EB002520, 2R01 DE016525-08, 3P41 EB002520 - 11W1]
- AFIRM [W81XWH-14-2-0004]
In the field of soft tissue reconstruction, custom implants could address the need for materials that can fill complex geometries. Our aim was to develop a material system with optimal rheology for material extrusion, that can be processed in physiological and non-toxic conditions and provide structural support for soft tissue reconstruction. To meet this need we developed silk based bioinks using gelatin as a bulking agent and glycerol as a non-toxic additive to induce physical crosslinking. We developed these inks optimizing printing efficacy and resolution for patient-specific geometries that can be used for soft tissue reconstruction. We demonstrated in vitro that the material was stable under physiological conditions and could be tuned to match soft tissue mechanical properties. We demonstrated in vivo that the material was biocompatible and could be tuned to maintain shape and volume up to three months while promoting cellular infiltration and tissue integration. (C) 2016 Elsevier Ltd. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据