期刊
CURRENT OPINION IN CHEMICAL BIOLOGY
卷 36, 期 -, 页码 70-76出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.cbpa.2017.01.012
关键词
-
资金
- [NIHU24 DK097154]
- [NIHHL113452]
- [NSFMCB 1611846]
- Div Of Molecular and Cellular Bioscience
- Direct For Biological Sciences [1611846] Funding Source: National Science Foundation
Enzymatic transformations of primary, canonical metabolites generate active biomolecules that regulate important cellular and physiological processes. Roles include regulation of histone demethylation in epigenetics, inflammation in tissue injury, insulin sensitivity, cancer cell invasion, stem cell pluripotency status, inhibition of nitric oxide signaling and others. Such modified compounds, defined as epimetabolites, have functions distinct from classic hormones as well as removed from generic anabolism and catabolism. Epimetabolites are discovered by untargeted metabolomics using liquid- or gas chromatography high resolution mass spectrometry and structurally annotated by in-silico fragmentation prediction tools. Their specific biological functions are subsequently investigated by targeted metabolomics methods.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据