期刊
BIOESSAYS
卷 39, 期 2, 页码 -出版社
WILEY
DOI: 10.1002/bies.201600113
关键词
annotation; Citrus; evolution; genome; microRNA; miRBase; mis-annotation; plant
资金
- Bristol Centre for Complexity Sciences (BCCS), an EPSRC centre for doctoral training (CDT) [EP/I013717/1]
- Royal Society Wolfson Merit Award
- NERC [NE/N003438/1]
- Faculty of Science, University of Bristol, UK
- Engineering and Physical Sciences Research Council [1098841] Funding Source: researchfish
- Natural Environment Research Council [NE/N003438/1] Funding Source: researchfish
- EPSRC [EP/I013717/1] Funding Source: UKRI
- NERC [NE/N003438/1] Funding Source: UKRI
MicroRNAs are non-coding regulators of gene expression and key factors in development, disease, and targets for bioengineering. Consequently, microRNAs have become essential elements of already burgeoning draft plant genome descriptions where their annotation is often particularly poor, contributing unduly to the corruption of public databases. Using the Citrus sinensis as an example, we highlight and review common failings of miRNAome annotations. Understanding and exploiting the role of miRNAs in plant biology will be stymied unless the research community acts decisively to improve the accuracy of miRNAome annotations. We encourage genome annotation teams to do it right or not at all.
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