期刊
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
卷 101, 期 3, 页码 987-1001出版社
SPRINGER
DOI: 10.1007/s00253-016-8083-6
关键词
Alcohol dehydrogenases; Biotechnological applications; Chiral pharmaceuticals; Fine chemicals
资金
- Research Project of the National Natural Science Foundation of China [21672190]
- Major Program for Key Science and Technology of Zhejiang Province of China [2014C03010]
Alcohol dehydrogenases (ADHs), which belong to the oxidoreductase superfamily, catalyze the interconversion between alcohols and aldehydes or ketones with high stereoselectivity under mild conditions. ADHs are widely employed as biocatalysts for the dynamic kinetic resolution of racemic substrates and for the preparation of enantiomerically pure chemicals. This review provides an overview of biotechnological applications for ADHs in the production of chiral pharmaceuticals and fine chemicals.
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