期刊
CURRENT OPINION IN BIOTECHNOLOGY
卷 43, 期 -, 页码 1-7出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.copbio.2016.07.002
关键词
-
资金
- Veni grant scheme of the Netherlands Organization of Scientific Research (NWO) [Veni 722.013.008]
Capillary electrophoresis-mass spectrometry has shown considerable potential for profiling polar ionogenic compounds in metabolomics. Hyphenation of capillary electrophoresis to mass spectrometry is generally performed via a sheath-liquid interface. However, the electrophoretic effluent is significantly diluted in this configuration thereby limiting the utility of this method for highly sensitive metabolomics studies. Moreover, in this set-up the intrinsically low-flow property of capillary electrophoresis is not effectively utilized in combination with electrospray ionization. Here, advancements that significantly improved the performance of capillary electrophoresis-mass spectrometry are considered, with a special emphasis on the sheathless porous tip interface. Attention is also devoted to various technical aspects that still need to be addressed to make capillary electrophoresis-mass spectrometry a robust approach for probing the polar metabolome.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据