期刊
CIRCULATION-CARDIOVASCULAR IMAGING
卷 10, 期 2, 页码 -出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1161/CIRCIMAGING.116.005379
关键词
body surface area; magnetic resonance imaging
资金
- National Heart, Lung, and Blood Institute [N01-HC-95159, N01-HC-95160, N01-HC-95161, N01-HC-95162, N01-HC-95163, N01-HC-95164, N01-HC-95165, N01-HC-95166, N01-HC-95167, N01-HC-95168, N01-HC-95169]
- National Center for Research Resources [UL1-TR-000040, UL1-TR-001079]
- National Institute for Health Research Cardiovascular Biomedical Research Unit at Barts
- Farr Institute of Health Informatics Research at University College London Partners from the Medical Research Council
- Arthritis Research United Kingdom
- British Heart Foundation
- Cancer Research United Kingdom
- Economic and Social Research Council
- Engineering and Physical Sciences Research Council
- National Institute of Health Research
- National Institute for Social Care and Health Research (Welsh Assembly Government)
- Chief Scientist Office (Scottish Government Health Directorates)
- Wellcome Trust [MR/K006584/1]
- British Heart Foundation [FS/10/40/28260, FS/12/56/29723] Funding Source: researchfish
- National Institute for Health Research [ACF-2014-19-002, CL-2016-19-501] Funding Source: researchfish
Background-Left atrial (LA) size is a marker of diastolic function and is associated with atrial fibrillation and cardiovascular outcomes. However, there are no large population studies measuring LA structure. The relationship of demographics and cardiovascular risk factors to LA size is largely unknown. This study aimed to determine associations of LA size with demographic factors, cardiac structure and function, and cardiovascular risk factors. Methods and Results-LA volume indexed to body surface area was measured by cardiovascular magnetic resonance steady-state free precession and fast gradient echo cine long-and short-axis images in 2576 asymptomatic participants of MESA ([Multi-Ethnic Study of Atherosclerosis] 68.7 years, 53.0% women, white 42.2%, Chinese American 12.0%, black 24.5%, and Hispanic 21.2%) using biplane and short-axis images. The mean LA volume index was 36.5 +/- 11.4 mL/m(2) in the entire cohort and 35.5 +/- 10.1 mL/m(2) in subjects free of cardiovascular risk factors (n=283). Multivariable analysis included adjustment for demographics, ethnicity, cardiovascular risk factors, serological studies, socioeconomic status, left ventricular structure, and medications. In the adjusted analysis, age (beta=0.2 mL/m(2) per year, P<0.0001), male sex (beta=-4.2 mL/m(2), P<0.0001), obesity (beta=1.3 mL/m(2), P<0.01), end-diastolic volume index (beta=0.4 mL/m(2), P<0.0001), Chinese American (beta=-2.6 mL/m(2), P<0.0001), and Hispanic (beta=1.1 mL/m(2), P<0.05) ethnicities were associated with LA volume index. Diabetes mellitus and smoking were not associated with LA volume index. LA volumes measured by steady-state free precession were 3% larger than by fast gradient echo cine cardiovascular magnetic resonance (P<0.001). Conclusions-Age, sex, ethnicity and left ventricular structural parameters were associated with LA size. Importantly, the study provides reference values of normal LA volume index.
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