期刊
CURRENT OPINION IN STRUCTURAL BIOLOGY
卷 42, 期 -, 页码 147-154出版社
CURRENT BIOLOGY LTD
DOI: 10.1016/j.sbi.2017.01.006
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资金
- Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases of the National Institutes of Health [ZIA DK075104-04]
Intrinsically disordered proteins (IDPs) are increasingly realized to play diverse biological roles, ranging from molecular signaling to the formation of membraneless organelles. Their high degree of disorder makes them more challenging to study using the techniques of conventional structural biology, because any observable will be averaged over a heterogeneous ensemble of structures. Molecular simulations and theory are therefore a natural complement to experiment for studying the structure, dynamics and function of IDPs. The diverse time and length scales relevant to the roles played by IDPs require flexibility in the techniques applied. Here, I summarize some of the developments in simulation and theory in recent years, which have been driven by the desire to better capture IDP properties at different time- and length-scales. I also provide an outlook for how methods can be improved in the future and emerging problems which may be addressed by theory and simulation.
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