期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 56, 期 7, 页码 1864-1868出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201611067
关键词
allenes; asymmetric catalysis; copper; diazo compounds; flow chemistry
资金
- Cambridge Home and European Scholarship Scheme
- Erasmus Scholarship Scheme
- Swiss National Science Foundation
- UCB Biopharma SPRL
- EPSRC [EP/ K009494/1, EP/ K039520/1, EP/ M004120/1]
- EPSRC [EP/K009494/1, EP/K039520/1, EP/M004120/1] Funding Source: UKRI
- Engineering and Physical Sciences Research Council [EP/M004120/1, EP/K009494/1] Funding Source: researchfish
We report herein the asymmetric coupling of flow-generated unstabilized diazo compounds and propargylated amine derivatives, using a new pyridinebis(imidazoline) ligand, a copper catalyst and base. The reaction proceeds rapidly, generating chiral allenes in 10-20 minutes with high enantioselectivity (89-98% de/ee), moderate yields and a wide functional group tolerance.
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