期刊
CARBOHYDRATE POLYMERS
卷 157, 期 -, 页码 603-612出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.carbpol.2016.10.029
关键词
Gamma irradiation; Sterilization; Ophthalmic drug delivery; Diclofenac sodium; N-Trimethyl chitosan nanoparticles
资金
- Thammasat University Research Fund [2/29/2557]
- Office of the Higher Education Commission, the Thailand Research Fund
- Thammasat University [MRG5580096]
This study was conducted to investigate the effect of gamma irradiation on physicochemical properties of N-trimethyl chitosan (TMC), diclofenac sodium (DC) and diclofenac sodium loaded N-trimethylchitosan nanoparticles (DC-TMCNs), and to determine suitable doses of gamma rays for sterilization of DC-TMCNs. Physicochemical properties of TMC, DC and DC-TMCNs before and after exposure to gamma rays at various doses were investigated. It was found that gamma irradiation at doses of 5-25 kGy did not cause any significant changes in physical and chemical properties of TMC, DC and DC-TMCNs. The bioburden of DC-TMCNs was 1.5 x 10(6) CFU/vial. The initial contaminating bacteria were radiosensitive bacteria. A number of microorganisms was reduced to 10(-6) after exposure to 9.9 kGy of gamma rays. Therefore, DC-TMCNs could be sterilized by gamma irradiation at a dose of 10 kGy, which did not alter their physicochemical properties and did not produce any substances toxic to the eye. (C) 2016 Elsevier Ltd. All rights reserved.
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