期刊
CELL
卷 168, 期 4, 页码 584-599出版社
CELL PRESS
DOI: 10.1016/j.cell.2016.12.015
关键词
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资金
- Prostate Cancer Foundation
- Sontag Foundation
- Josie Robertson Foundation
- Breast Cancer Research Foundation
- Geoffrey Beene Cancer Research Center
- Marie-Josee and Henry R. Kravis Center for Molecular Oncology
- Cycle for Survival
- National Institutes of Health [R01 CA190642-01A1, P50 CA092629, R01 CA207244, U54 OD202355, P30 CA008748]
Early successes in identifying and targeting individual oncogenic drivers, together with the increasing feasibility of sequencing tumor genomes, have brought forth the promise of genomedriven oncology care. As we expand the breadth and depth of genomic analyses, the biological and clinical complexity of its implementation will be unparalleled. Challenges include target credentialing and validation, implementing drug combinations, clinical trial designs, targeting tumor heterogeneity, and deploying technologies beyond DNA sequencing, among others. We review how contemporary approaches are tackling these challenges and will ultimately serve as an engine for biological discovery and increase our insight into cancer and its treatment.
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