期刊
CARBOHYDRATE POLYMERS
卷 157, 期 -, 页码 1853-1861出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.carbpol.2016.11.072
关键词
Succinyl-chitosan; Quercetin; Resveratrol; Liposome; Antioxidant; Oral delivery
资金
- Ministerio de Economia y Competitividad, Spain [BIO2014-52872-R]
- FEDER funds
- European Community [312284]
- Generalitat de Catalunya, Spain [2014-SGR-938]
- [MINECO-CTQ2013-41514-P]
In the present work, quercetin and resveratrol, natural polyphenols with strong antioxidant and anti-inflammatory properties, were co-loaded in polymer-associated liposomes conceived for oral delivery, by exploiting the potential of pH-sensitive succinyl-chitosan. Chitosan was succinylated, characterized by Nuclear Magnetic Resonance spectroscopy and Gel Permeation Chromatography, and used to form a protective shell on the surface of liposomes. The physico-chemical properties of the succinyl-chitosan liposomes were assessed by light scattering, zeta potential, cryogenic transmission electron microscopy, and small angle X-ray scattering. Small, spherical, uni- and bilamellar vesicles were produced. The succinyl-chitosan shell increased not only the physical stability of the vesicular system, as demonstrated by accelerated stability tests, but also the release of the polyphenols to a greater extent at pH 7.0, mimicking the intestinal environment. The proposed approach based on polyphenol vesicular formulations may be of value in the treatment of pre-cancerous/cancerous intestinal conditions associated with inflammation and oxidative stress. (C) 2016 Elsevier Ltd. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据