期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 56, 期 8, 页码 2054-2058出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201611850
关键词
alkenes; asymmetric catalysis; copper intermolecular reactions; radical reactions
资金
- National Basic Research Program of China [973-2015CB856600]
- National Natural Science Foundation of China [21225210, 21532009, 21421091, 21472217]
- Strategic Priority Research Program of the Chinese Academy of Sciences [XDB20000000]
- CAS
- Open Project Program of the Key Laboratory of Functional Small Organic Molecule, Ministry of Education, Jiangxi Normal University [KLFS-KF-201402]
Asymmetric copper-catalyzed intermolecular amino- and azidocyanation reactions of alkenes have been developed that proceed via a radical process in which a key benzylic radical intermediate is enantioselectively trapped by a chiral Box/Cu-II cyanide complex. A variety of enantiomerically enriched beta-amino/azido alkylnitriles were efficiently synthesized. The beta-azido alkylnitriles could be converted into a series of highly valuable optically active amine-based building blocks and bioactive compounds.
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