期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 56, 期 8, 页码 2097-2100出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201610722
关键词
cooperative catalysis; halofunctionalization; organocatalysis; photoredox catalysis; radicals
资金
- National Institutes of Health (NIGMS) Award [R01 GM098340]
- Eli Lilly Grantee Award
- UNC EFRC: Center for Solar Fuels, an Energy Frontier Research Center - U.S. Department of Energy, Office of Science, Office of Basic Energy Sciences [DE-SC0001011]
Halofunctionalization of alkenes is a classical method for olefin difunctionalization. It gives rise to adducts which are found in many natural products and biologically active molecules, and offers a synthetic handle for further manipulation. Classically, this reaction is performed with an electrophilic halogen source and leads to regioselective formation of the halofunctionalized adducts. Herein, we demonstrate a reversal of the native regioselectivity for alkene halofunctionalization through the use of an acridinium photooxidant in conjunction with a copper cocatalyst.
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