期刊
BRAIN RESEARCH BULLETIN
卷 128, 期 -, 页码 98-105出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.brainresbull.2016.11.008
关键词
A beta-peptide; Alzheimer; Platelets; Thrombosis
资金
- NIH/NIMHD [5SC2GM102040, 5G12MD007583, 1SC2GM111149, R25GM110513]
- NIH/NINDS SNRP [1U54N 5083924]
- NIH [R01HL90933]
Introduction: Platelets contain beta-amyloid precursor protein (APP) as well as A beta peptide (A beta) that can be released upon activation. During thrombosis, platelets are concentrated in clots and activated. Methods: We used in vivo fluorescent analysis and electron microscopy in mice to determine to what degree platelets are concentrated in clots. We used immunostaining to visualize A beta after photothrombosis in mouse brains. Results: Both in vivo results and electron microscopy revealed that platelets were 300-500 times more concentrated in clots than in non-clotted blood. After thrombosis in control mice, but not in thrombocytopenic animals, A beta immunofluorescence was present inside blood vessels in the visual cortex and around capillaries in the entorhinal cortex. Conclusion: The increased concentration of platelets allows enhanced release of A beta during thrombosis, suggesting an additional source of A beta in the brains of Alzheimer's patients that may arise if frequent micro-thrombosis events occur in their brains. (C) 2016 The Authors. Published by Elsevier Inc.
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