期刊
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
卷 7, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fcimb.2017.00435
关键词
Rab GTPase; macrophages; phagosomes; inflammation; innate immunity
资金
- Francis Crick Institute
- Cancer Research UK [FC001092]
- UK Medical Research Council [FC001092, MC_UP_1202/11]
- Wellcome Trust [FC001092]
- EMBO fellowship [ALTF1067-2015]
- The Francis Crick Institute [10484, 1067-2015, 10092] Funding Source: researchfish
Strict spatiotemporal control of trafficking events between organelles is critical for maintaining homeostasis and directing cellular responses. This regulation is particularly important in immune cells for mounting specialized immune defenses. By controlling the formation, transport and fusion of intracellular organelles, Rab GTPases serve as master regulators of membrane trafficking. In this review, we discuss the cellular and molecular mechanisms by which Rab GTPases regulate immunity and inflammation.
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