期刊
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷 27, 期 4, 页码 911-917出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2017.01.002
关键词
Mesoionic; Pyrido[1,2-a]pyrimidinone; Insecticide; Dicloromezotiaz; Acetylcholine receptor; Inhibitor
A novel class of mesoionic pyrido[1,2-a]pyrimidinones has been discovered with exceptional insecticidal activity controlling a number of insect species. In this communication, we report the part of the optimization program that led to the identification of dicloromezotiaz as a potent insecticide to control a broad range of lepidoptera. Our efforts in discovery, synthesis, structure-activity relationship elucidation, and biological activity evaluation are also presented. (C) 2017 Elsevier Ltd. All rights reserved.
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