期刊
ACS APPLIED MATERIALS & INTERFACES
卷 9, 期 7, 页码 5699-5708出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsami.6b12469
关键词
metal-organic frameworks; nanoscale metal-organic frameworks; two-photon excited fluorescence; photodynamic therapy; theranostics
资金
- Guangdong Innovative and Entrepreneurial Research Team Program [2013C090, KYPT20141013150545116]
Ruthenium(II) tris(bipyridyl) cationic complex (Ru(bpy)(3)(2+)) incorporated UiO-67 (Universitetet i Oslo) nanoscale metal organic frameworks (NMOFs) with an average diameter of similar to 92 nm were developed as theranostic nanoplatform for in vitro two-photon fluorescence imaging and photodynamic therapy. After incorporation into porous UiO-67 nanoparticles, the quantum yield, luminescence lifetime, and two-photon fluorescence intensity of Ru(bpy)(3)(2+) guest molecules were much improved owing to the steric confinement effect of MOF pores. Benefiting from these merits, the as-synthesized nanoparticles managed to be internalized by A549 cells while providing excellent red fluorescence in cytoplasm upon excitation with 880 nm irradiation. Photodynamic therapeutic application of the Ru(bpy)(3)(2+)-incorporated UiO-67 NMOFs was investigated in vitro. The Ru(bpy)(3)(2+)-incorporated UiO-67 NMOFs exhibited good biocompatibility without irradiation while having good cell-killing rates upon irradiation. In view of these facts, the developed Ru(bpy)(3)(2+)-incorporated NMOFs give a new potential pathway to achieve enhanced two-photon fluorescence imaging and photodynamic therapy.
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