期刊
ELIFE
卷 6, 期 -, 页码 -出版社
eLIFE SCIENCES PUBL LTD
DOI: 10.7554/eLife.21629
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资金
- Japan Society for the Promotion of Science
- Japan Agency for Medical Research and Development
- Ministry of Education, Culture, Sports, Science and Technology [KAKENHI JP23115704, KAKENHI JP21115504, KAKENHI JP16H06536, KAKENHI JP23115703, KAKENHI JP21115502, KAKENHI JP23115711, KAKENHI JP16H06545]
- Mitsubishi Foundation
- Shimadzu Science Foundation
- Takeda Science Foundation
- MRC [MR/N004574/1] Funding Source: UKRI
- Grants-in-Aid for Scientific Research [15K14310, 16H06536, 16H06535, 16K21735] Funding Source: KAKEN
- Medical Research Council [MR/N004574/1] Funding Source: researchfish
Brains regulate behavioral responses with distinct timings. Here we investigate the cellular and molecular mechanisms underlying the timing of decision-making during olfactory navigation in Caenorhabditis elegans. We find that, based on subtle changes in odor concentrations, the animals appear to choose the appropriate migratory direction from multiple trials as a form of behavioral decision-making. Through optophysiological, mathematical and genetic analyses of neural activity under virtual odor gradients, we further find that odor concentration information is temporally integrated for a decision by a gradual increase in intracellular calcium concentration ([Ca2+](i)), which occurs via L-type voltage-gated calcium channels in a pair of olfactory neurons. In contrast, for a reflex-like behavioral response, [Ca2+](i) rapidly increases via multiple types of calcium channels in a pair of nociceptive neurons. Thus, the timing of neuronal responses is determined by cell type-dependent involvement of calcium channels, which may serve as a cellular basis for decision-making.
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