期刊
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
卷 1864, 期 2, 页码 280-292出版社
ELSEVIER
DOI: 10.1016/j.bbamcr.2016.11.009
关键词
Light-inducible systems; Optogenetics; Photoreceptors; Protein-protein-interaction; Signal transduction; Synthetic biology
资金
- Excellence Initiative of the German Federal and State Governments [EXC-294 BIOSS]
Cells receive many different environmental clues to which they must adapt accordingly. Therefore, a complex signal transduction network has evolved. Cellular signal transduction is a highly dynamic process, in which the specific outcome is a result of the exact spatial and temporal resolution of single sub-events. While conventional techniques, like chemical inducer systems, have led to a sound understanding of the architecture of signal transduction pathways, the spatiotemporal aspects were often impossible to resolve. Optogenetics, based on genetically encoded light-responsive proteins, has the potential to revolutionize manipulation of signal transduction processes. Light can be easily applied with highest precision and minimal invasiveness. This review focuses on examples of optogenetic systems which were generated and applied to manipulate non-neuronal mammalian signaling processes at various stages of signal transduction, from cell membrane through cytoplasm to nucleus. Further, the future of optogenetic signaling will be discussed. (C) 2016 Elsevier B.V. All rights reserved.
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