期刊
ELIFE
卷 6, 期 -, 页码 -出版社
ELIFE SCIENCES PUBLICATIONS LTD
DOI: 10.7554/eLife.20975
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资金
- Fundacao para a Ciencia e Tecnologia [SFRH / BD / 33277 / 2007]
- Human Frontier Science Program [LT000881/2011L]
- Fundacaopara a Ciencia e Tecnologia [SFRH/BD/51210/2010]
- Howard Hughes Medical Institute International Early Career Scientist
- European Research Council Starting Investigator Grant [640093]
- European Research Council Advanced Investigator Grant [250334, 671251]
- Champalimaud Foundation
- Fundação para a Ciência e a Tecnologia [SFRH/BD/51210/2010, SFRH/BD/33277/2007] Funding Source: FCT
- European Research Council (ERC) [640093] Funding Source: European Research Council (ERC)
Serotonin (5-HT) is associated with mood and motivation but the function of endogenous 5-HT remains controversial. Here, we studied the impact of phasic optogenetic activation of 5-HT neurons in mice over time scales from seconds to weeks. We found that activating dorsal raphe nucleus (DRN) 5-HT neurons induced a strong suppression of spontaneous locomotor behavior in the open field with rapid kinetics (onset <= 1 s). Inhibition of locomotion was independent of measures of anxiety or motor impairment and could be overcome by strong motivational drive. Repetitive place-contingent pairing of activation caused neither place preference nor aversion. However, repeated 15 min daily stimulation caused a persistent increase in spontaneous locomotion to emerge over three weeks. These results show that 5-HT transients have strong and opposing short and long-term effects on motor behavior that appear to arise from effects on the underlying factors that motivate actions.
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