期刊
BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS
卷 1860, 期 1, 页码 31-40出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.bbagrm.2016.07.005
关键词
Transcription factor; cis-regulatory element; Protein-protein interactions; Histone mark; MYB; bHLH
资金
- National Science Foundation [IOS-1125620, MCB-1513807]
- Direct For Biological Sciences
- Division Of Integrative Organismal Systems [1125620] Funding Source: National Science Foundation
- Div Of Molecular and Cellular Bioscience
- Direct For Biological Sciences [1513807] Funding Source: National Science Foundation
Combinatorial gene regulation provides a mechanism by which relatively small numbers of transcription factors can control the expression of a much larger number of genes with finely tuned temporal and spatial patterns. This is achieved by transcription factors assembling into complexes in a combinatorial fashion, exponentially increasing the number of genes that they can target. Such an arrangement also increases the specificity and affinity for the cis-regulatory sequences required for accurate target gene expression. Superimposed on this transcription factor combinatorial arrangement is the increasing realization that histone modification marks expand the regulatory information, which is interpreted by histone readers and writers that are part of the regulatory apparatus. Here, we review the progress in these areas from the perspective of plant combinatorial gene regulation, providing examples of different regulatory solutions and comparing them to other metazoans. This article is part of a Special Issue entitled: Plant Gene Regulatory Mechanisms and Networks, edited by Dr. Erich Grotewold and Dr. Nathan Springer. (C) 2016 Elsevier B.V. All rights reserved.
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