相关参考文献
注意：仅列出部分参考文献，下载原文获取全部文献信息。RNA mis-splicing in disease
Marina M. Scotti et al.
NATURE REVIEWS GENETICS (2016)
Multiple protein-protein interactions converging on the Prp38 protein during activation of the human spliceosome
Tonio Schuetze et al.
RNA (2016)
Design and synthesis of natural product derivatives with selective and improved cytotoxicity based on a sesquiterpene scaffold
Yang Zhang et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2016)
Cryo-EM structure of the yeast U4/U6.U5 tri-snRNP at 3.7 Å resolution
Thi Hoang Duong Nguyen et al.
NATURE (2016)
Cryo-EM structure of the spliceosome immediately after branching
Wojciech P. Galej et al.
NATURE (2016)
Molecular architecture of the human U4/U6.U5 tri-snRNP
Dmitry E. Agafonov et al.
SCIENCE (2016)
The 3.8 Å structure of the U4/U6.U5 tri-snRNP: Insights into spliceosome assembly and catalysis
Ruixue Wan et al.
SCIENCE (2016)
Structure of a yeast catalytic step I spliceosome at 3.4 Å resolution
Ruixue Wan et al.
SCIENCE (2016)
Molecular architecture of the Saccharomyces cerevisiae activated spliceosome
Reinhard Rauhut et al.
SCIENCE (2016)
Structure of a yeast activated spliceosome at 3.5 Å resolution
Chuangye Yan et al.
SCIENCE (2016)
A spliceosome intermediate with loosely associated tri-snRNP accumulates in the absence of Prp28 ATPase activity
Carsten Boesler et al.
NATURE COMMUNICATIONS (2016)
Single molecule analysis reveals reversible and irreversible steps during spliceosome activation
Aaron A. Hoskins et al.
ELIFE (2016)
Modulation of Alternative Splicing with Chemical Compounds in New Therapeutics for Human Diseases
Kenji Ohe et al.
ACS CHEMICAL BIOLOGY (2015)
Protein localisation by electron microscopy reveals the architecture of the yeast spliceosomal B complex
Norbert Rigo et al.
EMBO JOURNAL (2015)
A novel mechanism for Prp5 function in prespliceosome formation and proofreading the branch site sequence
Wen-Wei Liang et al.
GENES & DEVELOPMENT (2015)
The Natural Product N-Palmitoyl-L-leucine Selectively Inhibits Late Assembly of Human Spliceosomes
Kerstin A. Effenberger et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2015)
Stable tri-snRNP integration is accompanied by a major structural rearrangement of the spliceosome that is dependent on Prp8 interaction with the 5′ splice site
Carsten Boesler et al.
RNA (2015)
Structural basis of pre-mRNA splicing
Jing Hang et al.
SCIENCE (2015)
Structure of a yeast spliceosome at 3.6-angstrom resolution
Chuangye Yan et al.
SCIENCE (2015)
Identification of Small Molecule Inhibitors of Pre-mRNA Splicing
Andrea Pawellek et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2014)
Evidence for a group II intron-like catalytic triplex in the spliceosome
Sebastian M. Fica et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2014)
Remodeling of U2-U6 snRNA helix I during pre-mRNA splicing by Prp16 and the NineTeen Complex protein Cwc2
Rebecca Hogg et al.
NUCLEIC ACIDS RESEARCH (2014)
An efficient continuous flow approach to furnish furan-based biaryls
Trieu N. Trinh et al.
ORGANIC & BIOMOLECULAR CHEMISTRY (2014)
Cyplecksins Are Covalent Inhibitors of the Pleckstrin Homology Domain of Cytohesin
Mohamed Hussein et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2013)
RNA structure analysis of human spliceosomes reveals a compact 3D arrangement of snRNAs at the catalytic core
Maria Anokhina et al.
EMBO JOURNAL (2013)
RNA catalyses nuclear pre-mRNA splicing
Sebastian M. Fica et al.
NATURE (2013)
A High-Throughput Splicing Assay Identifies New Classes of Inhibitors of Human and Yeast Spliceosomes
Kerstin A. Effenberger et al.
JOURNAL OF BIOMOLECULAR SCREENING (2013)
Small-molecular inhibitors of Ca2+-induced mitochondrial permeability transition (MPT) derived from muscle relaxant dantrolene
Shinpei Murasawa et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2012)
Psoromic Acid Derivatives: A New Family of Small-Molecule Pre-mRNA Splicing Inhibitors Discovered by a Stage-Specific High-Throughput in Vitro Splicing Assay
Timur R. Samatov et al.
CHEMBIOCHEM (2012)
Cwc2 and its human homologue RBM22 promote an active conformation of the spliceosome catalytic centre
Nicolas Rasche et al.
EMBO JOURNAL (2012)
A Quantitative High-Throughput In Vitro Splicing Assay Identifies Inhibitors of Spliceosome Catalysis
Michael G. Berg et al.
MOLECULAR AND CELLULAR BIOLOGY (2012)
The spliceosome as a target of novel antitumour drugs
Sophie Bonnal et al.
NATURE REVIEWS DRUG DISCOVERY (2012)
Crystal structure of a group II intron in the pre-catalytic state
Russell T. Chan et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2012)
Molecular architecture of zinc chelating small molecules that inhibit spliceosome assembly at an early stage
Vishal Patil et al.
RNA (2012)
Structure of the yeast U2/U6 snRNA complex
Jordan E. Burke et al.
RNA (2012)
New connections between splicing and human disease
Richard A. Padgett
TRENDS IN GENETICS (2012)
Pre-mRNA splicing in disease and therapeutics
Ravi K. Singh et al.
TRENDS IN MOLECULAR MEDICINE (2012)
Post-transcriptional spliceosomes are retained in nuclear speckles until splicing completion
Cyrille Girard et al.
NATURE COMMUNICATIONS (2012)
The mechanism of the second step of pre-mRNA splicing
David S. Horowitz
WILEY INTERDISCIPLINARY REVIEWS-RNA (2012)
Sudemycins, Novel Small Molecule Analogues of FR901464, Induce Alternative Gene Splicing
Liying Fan et al.
ACS CHEMICAL BIOLOGY (2011)
Identification of SAP155 as the Target of GEX1A (Herboxidiene), an Antitumor Natural Product
Makoto Hasegawa et al.
ACS CHEMICAL BIOLOGY (2011)
Reduced fidelity of branch point recognition and alternative splicing induced by the anti-tumor drug spliceostatin A
Anna Corrionero et al.
GENES & DEVELOPMENT (2011)
The anti-tumor drug E7107 reveals an essential role for SF3b in remodeling U2 snRNP to expose the branch point-binding region
Eric G. Folco et al.
GENES & DEVELOPMENT (2011)
Semiquantitative Proteomic Analysis of the Human Spliceosome via a Novel Two-Dimensional Gel Electrophoresis Method
Dmitry E. Agafonov et al.
MOLECULAR AND CELLULAR BIOLOGY (2011)
Molecular Architecture of the Human Prp19/CDC5L Complex
Michael Grote et al.
MOLECULAR AND CELLULAR BIOLOGY (2010)
Exon Definition Complexes Contain the Tri-snRNP and Can Be Directly Converted into B-like Precatalytic Splicing Complexes
Marc Schneider et al.
MOLECULAR CELL (2010)
Spliceostatin A inhibits spliceosome assembly subsequent to prespliceosome formation
Gabriel A. Roybal et al.
NUCLEIC ACIDS RESEARCH (2010)
Characterization of purified human B act spliceosomal complexes reveals compositional and morphological changes during spliceosome activation and first step catalysis
Sergey Bessonov et al.
RNA (2010)
The Spliceosome: Design Principles of a Dynamic RNP Machine
Markus C. Wahl et al.
CELL (2009)
Bright, Color-Tunable Fluorescent Dyes in the Vis/NIR Region: Establishment of New Tailor-Made Multicolor Fluorophores Based on Borondipyrromethene
Keitaro Umezawa et al.
CHEMISTRY-A EUROPEAN JOURNAL (2009)
Investigation of N-Aryl-3-alkylidenepyrrolinones as Potential Niemann-Pick Type C Disease Therapeutics
Casey C. Cosner et al.
JOURNAL OF MEDICINAL CHEMISTRY (2009)
Establishment of Broadly Applicable Reaction Conditions for the Palladium-Catalyzed Direct Arylation of Heteroatom-Containing Aromatic Compounds
Benoit Liegault et al.
JOURNAL OF ORGANIC CHEMISTRY (2009)
The Evolutionarily Conserved Core Design of the Catalytic Activation Step of the Yeast Spliceosome
Patrizia Fabrizio et al.
MOLECULAR CELL (2009)
Single-molecule analysis of protein-free U2-U6 snRNAs
Zhuojun Guo et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2009)
Stalling of spliceosome assembly at distinct stages by small-molecule inhibitors of protein acetylation and deacetylation
Andreas N. Kuhn et al.
RNA (2009)
The Biflavonoid Isoginkgetin Is a General Inhibitor of Pre-mRNA Splicing
Kristine O'Brien et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2008)
Isolation of an active step I spliceosome and composition of its RNP core
Sergey Bessonov et al.
NATURE (2008)
Phosphorylation of human PRP28 by SRPK2 is required for integration of the U4/U6-U5 tri-snRNP into the spliceosome
Rebecca Mathew et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2008)
Mechanistic insights from reversible splicing catalysis
Duncan J. Smith et al.
RNA (2008)
GraFix: sample preparation for single-particle electron cryomicroscopy
Berthold Kastner et al.
NATURE METHODS (2008)
Splicing factor SF3b as a target of the antitumor natural product pladienolide
Yoshihiko Kotake et al.
NATURE CHEMICAL BIOLOGY (2007)
Spliceostatin A targets SF3b and inhibits both splicing and nuclear retention of pre-mRNA
Daisuke Kaida et al.
NATURE CHEMICAL BIOLOGY (2007)
U2 toggles iteratively between the stem IIa and stem IIc conformations to promote pre-mRNA splicing
Angela K. Hilliker et al.
GENES & DEVELOPMENT (2007)
Rearrangement of competing U2 RNA helices within the spliceosome promotes multiple steps in splicing
Rhonda J. Perriman et al.
GENES & DEVELOPMENT (2007)
Selective inhibition of topoisomerase I and various steps of spliceosome assembly by diospyrin derivatives
J Tazi et al.
MOLECULAR PHARMACOLOGY (2005)
Non-thiol farnesyltransferase inhibitors:: N-(4-tolylacetylamino3-benzoylphenyl)-3-arylfurylacrylic acid amides
A Mitsch et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2004)
U2-U6 RNA folding reveals a group II intron-like domain and a four-helix junction
DG Sashital et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2004)
A subset of human 35S U5 proteins, including Prp19, function prior to catalytic step 1 of splicing
OV Makarova et al.
EMBO JOURNAL (2004)
The Prp19p-associated complex in spliceosome activation
SP Chan et al.
SCIENCE (2003)
Intramolecular reactions of alkynes with furans and electron rich arenes catalyzed by PtCl2:: The role of platinum carbenes as intermediates
B Martín-Matute et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2003)
Small nuclear ribonucleoprotein remodeling during catalytic activation of the spliceosome
EM Makarov et al.
SCIENCE (2002)
Splicing regulation at the second catalytic step by sex-lethal involves 3′ splice site recognition by SPF45
MJ Lallena et al.
CELL (2002)
Phenylureas. Part 1. Mechanism of the basic hydrolysis of phenylureas
R Laudien et al.
JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 2 (2001)
SPF30 is an essential human splicing factor required for assembly of the U4/U5/U6 tri-small nuclear ribonucleoprotein into the spliceosome
J Rappsilber et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
A novel U2 and U11/U12 snRNP protein that associates with the pre-mRNA branch site
CL Will et al.
EMBO JOURNAL (2001)
The 65 and 110 kDa SR-related proteins of the U4/U6•U5 tri-snRNP are essential for the assembly of mature spliceosomes
OV Makarova et al.
EMBO JOURNAL (2001)
SMNrp is an essential pre-mRNA splicing factor required for the formation of the mature spliceosome
G Meister et al.
EMBO JOURNAL (2001)
分享论文
