期刊
ELIFE
卷 6, 期 -, 页码 -出版社
ELIFE SCIENCES PUBLICATIONS LTD
DOI: 10.7554/eLife.21540
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资金
- Christopher and Dana Reeve Foundation
- Mary K. Chapman Foundation
- Rose Hills Foundation
- University of California San Diego
- Howard Hughes Medical Institute
- National Institute of Neurological Disorders and Stroke
- US National Research Service Award
- National Science Foundation
- Ministry of Education, Culture, Sports, Science and Technology
- Timken-Sturgis Foundation
- National Institute of Neurological Disorders and Stroke [F31-NS080340-03, NS090919]
- California Institute for Regenerative Medicine
- Benjamin H. Lewis Chair
- National Cancer Institute [CCSG:P30014195]
- Marshall Heritage Foundation
- Sol Goldman Charitable Trust
Flexible neural networks, such as the interconnected spinal neurons that control distinct motor actions, can switch their activity to produce different behaviors. Both excitatory (E) and inhibitory (I) spinal neurons are necessary for motor behavior, but the influence of recruiting different ratios of E-to-I cells remains unclear. We constructed synthetic microphysical neural networks, called circuitoids, using precise combinations of spinal neuron subtypes derived from mouse stem cells. Circuitoids of purified excitatory interneurons were sufficient to generate oscillatory bursts with properties similar to in vivo central pattern generators. Inhibitory V1 neurons provided dual layers of regulation within excitatory rhythmogenic networks - they increased the rhythmic burst frequency of excitatory V3 neurons, and segmented excitatory motor neuron activity into sub-networks. Accordingly, the speed and pattern of spinal circuits that underlie complex motor behaviors may be regulated by quantitatively gating the intra-network cellular activity ratio of E-to-I neurons.
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